What is The Difference Between PRP and PRF?

What is The Difference Between PRP and PRF

Platelet-rich plasma, often known as PRP, has been used for many years to heal orthopedic injuries. But a second similar treatment is available today called PRF (or platelet-rich fibrin).

However, despite how similar the treatments seem and how they are applied, PRF is fundamentally different from PRP. Today, Eastside Aesthetics by Lena will help you discover the difference between the two. 

Check this post to learn more about PRP and PRF and which treatment could be the best one for you. 

All About PRP and PRF

Your blood contains natural growth factors called PRP and PRF. These chemicals, abundant in platelets, white blood cells, and fibrin, promote the growth of new skin cells, collagen, and elastin. 

Both procedures reduce fine lines and wrinkles, enhance tone and texture, and reduce the appearance of dark spots and other aging symptoms. Under dark eye circles, nasolabial folds, cheeks, smile lines, lips, and chin are common conditions treated with PRP and PRF. 

Most patients also decide to use it to firm the hands, décolleté, and neck, as well as on the scalp, to promote hair development.

So, How Does PRP Differ From PRF?

PRP and PRF function by accelerating the creation of collagen and new cells. Your blood’s platelets become activated and release growth factors when your body is harmed, in this case by microneedling or an injection. 

New skin cells, collagen, elastin, and blood vessels are produced due to these growth factors, which also help the wound begin healing. As a result, the skin becomes firmer and plumper, and fine wrinkles and dark spots disappear.

What Separates PRP From PRF?

The main distinction between these procedures is how your blood is drawn before the procedure. With PRP, the plasma layer in your blood is separated by rapid centrifugal spinning in a centrifuge. 

Your blood is spun less quickly during PRF, allowing specific white blood cells, stem cells, and fibrin to stay in the platelet layer. Because fewer cells are injured due to the slow spin, more healing platelets are present. 

Compared to PRP, PRF has a platelet concentration that is roughly 2–5 times higher than the body. The usage of anticoagulants is another obvious distinction. A vial of anticoagulants, which stop the blood from clotting during injection, is given as PRP therapy. 

Anticoagulants are not added when using PRF. As a result, a porous fibrin matrix can be produced, signaling the platelets to release their growth factors gradually. 

Growth factors are released by PRF for up to a week, while PRP only does so for a few hours. It is believed that the effects of this delayed-release will be more vital and more enduring.

PRF at Eastside Aesthetics by Lena

Our PRF treatment here at Eastside Aesthetics by Lena is an innovative cosmetic injectable that can naturally renew the skin and repair age symptoms. The next generation of PRF has tremendous healing and regeneration characteristics since it contains nearly ten times as many platelets as regular blood. 

Mesenchymal stem cells, platelets, leukocytes, and growth factors in PRF increase collagen and elastin synthesis, resulting in tighter, more even skin. PRF is an excellent procedure for enhancing the texture and tone of the skin because it increases collagen. 

For difficult-to-treat areas like the under-eye region, PRF is particularly successful. Additionally, it can stop hair loss, lessen the visibility of stretch marks, increase breast volume, boost lip color and hydration, and rejuvenate the entire face.

The Benefits of PRF

  • 100% autologous components
  • Free of any additional features like anticoagulants or bovine thrombin gel
  • In the absence of blood manipulation, there are significantly more living cells.
  • After treatment, growth factors continue to be secreted for several days (not hours).
  • It has more stem cells and healing components and causes less tissue stress when injected.

The final distinction is in the application of the remedies. While PRF is utilized as a filler, PRP is usually conducted as a face or microneedling treatment. 

This natural filler is an excellent substitute for synthetic fill because it contains fibrin and slow-release growth elements that help the skin gain volume.

Treatments For PRF at Eastside Aesthetics by Lena

If you’re wondering if there’s only one PRF treatment that you can do, you’re eventually wrong. Here’s what you can expect to get here at our clinic. 

Facial Rejuvenation with PRF

To increase the creation of elastin and collagen, we use your own blood’s therapeutic abilities. While PRF microneedling is one of the most special treatments for skin tone and texture, PRF injections penetrate deeper layers of the skin when administered to specific regions. This procedure, in contrast to dermal fillers, is entirely natural.

For Tired Eyes: PRF Refresh

With PRF, you can treat crepey skin, hollow tear troughs, and dark circles under your eyes. A potent concentration of your blood’s platelets, white blood cells, stem cells, and growth factor. 

Still, getting 2-3 treatments spaced out by a month is advised. We also offer a PRF Refresh Package Deal. 


PRF can be combined with the collagen-builder Sculptra to accelerate collagen and elastin production, giving the face a more youthful appearance and regaining lost facial volume. 

Results with PlasmaSculpt take around four weeks to manifest but can last up to 2 years or more. Three treatments spaced 4-6 weeks apart are advised for optimal results. If you wish to get the PlasmaSculpt Package, don’t hesitate to try it! 

Which Treatments Are Still Best?

PRP works best on people with hyperpigmentation, acne scars, fine lines, and wrinkles. Within a month, you ought to notice a change in the texture of your skin and fewer scarring and dark patches. 

PRP takes 3–4 treatments spaced four weeks apart for best results. When treating deep wrinkles or hollows, PRP is less effective. You can treat the same problems with PRP and PRF. However, PRF is preferable if you have deeper wrinkles, hollows, or more pronounced indications of aging. 

Because it is so good at generating volume, PRF is frequently referred to as a natural filler. Following your treatment, you can anticipate improvements in two to three weeks and a more noticeable difference in four to six weeks. 

PRF requires a minimum of 2 treatments spaced out by six months for best outcomes. The results can differ if you mix PRF with additional medicines like microneedling. Again, both PRP and PRF treatments have a very minimal risk of side effects because they use your blood. 

But you are not a good candidate for PRP or PRF treatments if you have a blood or bleeding disorder or take anti-clotting or blood-thinning drugs. Whatever procedure you select, your inherent beauty will shine through.

Schedule your PRF Treatment Today

You can contact us directly at Eastside Aesthetics by Lena if you have more questions regarding these procedures or our other policies. 

We’re happy to provide PRP and PRF services because they are tried-and-true procedures with many advantages. So, please book an appointment or contact us now! 

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